HappyKB
on October 7, 2025
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Jack tries Mescaline in October and October 7, 1960 Kerouac had the opportunity to try Ayahuasca
In the period surrounding both the events depicted in Big Sur and the writing and editing of the book, Jack actively experimented with certain psychedelic substances that hadn’t yet made a large impression on the American culture: mescaline, ayahuasca, and psilocybin mushrooms. At the start of Big Sur, he mentions some of these substances in a slightly negative manner, as if to suggest that they had worsened his overall mental condition: “. . . ‘One fast move or I’m gone,’ I realize, gone the way of the last three years of drunken hopelessness which is a physical and spiritual and metaphysical hopelessness you cant learn in school no matter how many books on existentialism or pessimism you read, or how many jugs of vision-producing Ayahuasca you drink, or Mescaline take, or Peyote goop up with—” (4).
However, this can’t be the whole story, since Kerouac’s letters offer an entirely different view on his psychonautic exploration during this time. Jack first tried mescaline in October 1959 (5), and he was apparently most open about it with Allen Ginsberg, to whom he wrote the following on June 20, 1960: “When on mescaline I was so bloody high I saw that all our ideas about a ‘beatific’ new gang of worldpeople, and about instantaneous truth being the last truth. Etc. etc. I saw them as all perfectly correct and prophesied, as never on drinking or sober I saw it — Like an Angel looking back on life sees that every moment fell right into place and each had flowery meaning…” (6). This kind of clarity must have been cherished by a guy who saw his life as a long chain of rambling misadventures. Kerouac was even moved to create a 5,000-word “Mescaline Report” in order to document his hallucinations and revelations. He said he intended to take mescaline monthly, and he couldn’t wait to test out LSD (lysergic acid diethylamide). In the same letter Kerouac mentioned his intention to flee New York, shortly before Ferlinghetti suggested that Jack use his cabin as an escape. The actual trip lasted about two months, from mid-July to mid-September 1960.
After returning from California, Kerouac had the opportunity to try ayahuasca on October 7, 1960 (7). Ginsberg had just visited South America and brought back some of the liquid preparation, also known as “yagé” (pronounced “yah-hey,” but they usually misspelled it as “yage”). William S. Burroughs had done the same in the early 1950s, as documented in his fictionalized letters titled “In Search of Yage” (written in ’53 but not published until ’63). Kerouac seems to have tasted the real thing, since, according to Ginsberg (writing during the event), Jack remarked, “This is one of the most sublime or tender or lovely moments of all our lives together . . .” (????. That’s not to say the experience was only positive. In June 1963 Jack reflected to Allen that, when he would wander into Manhattan for drinking binges, “I come back [to Long Island] with visions of horror as bad as Ayahuasca vision on the neanderthal million years in caves, the gruesomeness of life!” (9).
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